Exploring Transcriptional Regulatory Networks in the Worm
نویسندگان
چکیده
Using a yeast one-hybrid assay, Deplancke et al. (2006) report in this issue a protein-DNA interaction network for 72 gene promoters and 117 regulatory proteins expressed in cells of the nematode digestive tract. This study is a first step toward mapping transcriptional regulatory networks in distinct metazoan cell lineages and organs using a "gene-centered" approach.
منابع مشابه
Prediction and integration of regulatory and protein-protein interactions.
Knowledge of transcriptional regulatory interactions (TRIs) is essential for exploring functional genomics and systems biology in any organism. While several results from genome-wide analysis of transcriptional regulatory networks are available, they are limited to model organisms such as yeast ( 1 ) and worm ( 2 ). Beyond these networks, experiments on TRIs study only individual genes and prot...
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ورودعنوان ژورنال:
- Cell
دوره 125 شماره
صفحات -
تاریخ انتشار 2006